Dr Helder Ferreira


BMS B303
tel. 01334 463425
fax. 01334 462495

My research focusses on chromatin structure and dynamics. In particular, I am interested in ATP-dependent chromatin remodeling enzymes and telomere maintenance. My aim is to combine chemical genetics with in vitro biochemistry to obtain mechanistic insight into novel chromatin remodeling enzymes and the means by which they affect telomere function. 



Ferreira, HC, Towbin, BD, Jegou, T & Gasser, SM 2013, 'The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery' Journal of Cell Biology, vol 203, no. 5, pp. 727-735. DOI: 10.1083/jcb.201307181
Kueng, S, Tsai-Pflugfelder, M, Oppikofer, M, Ferreira, HC, Roberts, E, Tsai, C, Roloff, T-C, Sack, R & Gasser, SM 2012, 'Regulating repression: roles for the Sir4 N-terminus in linker DNA protection and stabilization of epigenetic states' PLoS Genetics, vol 8, no. 5, e1002727. DOI: 10.1371/journal.pgen.1002727
Ferreira, HC, Luke, B, Schober, H, Kalck, V, Lingner, J & Gasser, SM 2011, 'The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast' Nature Cell Biology, vol 13, no. 7, pp. 867-874. DOI: 10.1038/ncb2263
Schober, H, Ferreira, HC, Kalck, R, Gehlen, LR & Gasser, SM 2009, 'Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination' Genes & Development, vol 23, no. 8, pp. 928-938. DOI: 10.1101/gad.1787509
Chang, EY, Ferreira, H, Somers, J, Nusinow, DA, Owen-Hughes, T & Narlikar, GJ 2008, 'MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF' Biochemistry, vol 47, no. 51, pp. 13726-13732. DOI: 10.1021/bi8016944
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Dr Helder Ferreira Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST

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