Dr Laura Aitken

Research Fellow

MBS 137
tel. 01334 461863
fax.
la49@st-andrews.ac.uk

 

Publications

Benek, O, Hroch, L, Aitken, L, Gunn-Moore, F, Vinklarova, L, Kuca, K, Perez, DI, Perez, C, Martinez, A, Fisar, Z & Musilek, K 2018, '1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders' Journal of Enzyme Inhibition and Medicinal Chemistry, vol 33, no. 1, pp. 665-670. DOI: 10.1080/14756366.2018.1445736
Aitken, L, Baillie, G, Pannifer, A, Morrison, A, Jones, PS, Smith, TK, McElroy, SP & Gunn-Moore, FJ 2017, 'In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease' SLAS Discovery, vol 22, no. 6, pp. 676-685. DOI: 10.1177/247255521769796
Benek, O, Hroch, L, Aitken, L, Dolezal, R, Guest, P, Benkova, M, Soukup, O, Musil, K, Hughes, R, Kuca, K, Smith, TK, Gunn-Moore, F & Musilek, K 2017, '6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: design, synthesis and in vitro evaluation' Medicinal Chemistry, vol 13, no. 4, pp. 345-358. DOI: 10.2174/1573406413666170109142725
Hroch, L, Guest, P, Benek, O, Soukup, O, Janockova, J, Dolezal, R, Kuca, K, Aitken, L, Smith, TK, Gunn-Moore, F, Zala, D, Ramsay, RR & Musilek, K 2017, 'Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment' Bioorganic & Medicinal Chemistry, vol 25, no. 3, pp. 1143-1152. DOI: 10.1016/j.bmc.2016.12.029
Hroch, L, Benek, O, Guest, P, Aitken, L, Soukup, O, Janockova, J, Musil, K, Dohnal, V, Dolezal, R, Kuca, K, Smith, TK, Gunn-Moore, FJ & Musilek, K 2016, 'Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment' Bioorganic and Medicinal Chemistry Letters, vol 26, no. 15, pp. 3675-3678. DOI: 10.1016/j.bmcl.2016.05.087
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