Dr Louise Major

Research Fellow

BMS Level 3 Annex
tel. 01334 467265
fax. 01334 462595
llm6@st-andrews.ac.uk

Louise Major is a research fellow investigating key enzymes in lipid and GPI anchor biosynthesis in trypanosomes.

Louise's PhD (University of Otago, New Zealand) focused on termination of protein synthesis in E. coli. Since then she has worked in structural biology and enzymology. Her history of working with epimerase and isomerase enzymes is continuing with work with TbIno1. Along with genetic and chemical validation of drug targets, Louise is subjecting some drug targets to structural studies.

 

Publications

González-Salgado, A, Steinmann, M, Major, LL, Sigel, E, Reymond, J-L, Smith, TK & Bütikofer, P 2015, 'Trypanosoma brucei bloodstream forms depend upon uptake of myo-inositol for Golgi phosphatidylinositol synthesis and normal cell growth' Eukaryotic Cell, vol 14, no. 6, pp. 616-624. DOI: 10.1128/EC.00038-15
Lilley, AC, Major, LL, Young, S, Stark, MJR & Smith, TK 2014, 'The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei' Molecular Microbiology, vol 92, no. 3, pp. 453-470. DOI: 10.1111/mmi.12553
Pirrie, L, McCarthy, AR, Major, LL, Morkunaite, V, Zubriene, A, Matulis, D, Lain, S, Lebl, T & Westwood, NJ 2012, 'Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a 1H-NMR method to assess deacetylase activity' Molecules, vol 17, no. 10, pp. 12206-12224. DOI: 10.3390/molecules171012206
Tamborini, L, Pinto, A, Smith, TK, Major, LL, Iannuzzi, MC, Cosconati, S, Marinelli, L, Novellino, E, Lo Presti, L, Wong, PE, Barrett, MP, De Micheli, C & Conti, P 2012, 'Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis' ChemMedChem, vol 7, no. 9, pp. 1623-1634. DOI: 10.1002/cmdc.201200304
Conti, P, Pinto, A, Wong, PE, Major, LL, Tamborini, L, Iannuzzi, MC, De Micheli, C, Barrett, MP & Smith, TK 2011, 'Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor' ChemMedChem, vol 6, no. 2, pp. 329-333. DOI: 10.1002/cmdc.201000417
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