Prof Malcolm White

Professor

BMS 307 Annexe
tel. 01334 463432
fax. 01334 462595
mfw2@st-andrews.ac.uk

Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and  DNA repair mechanisms. We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics.

The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectrometry and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.

 

Publications

Rollie, C, Graham, S, Rouillon, CMJ & White, MF 2017, 'Prespacer processing and specific integration in a Type I-A CRISPR system' Nucleic Acids Research, vol Advance articles. DOI: 10.1093/nar/gkx1232
Peeters, E, Boon, M, Rollie, CJC, Willaert, RG, Voet, M, White, MF, Prangishvili, D, Lavigne, R & Quax, TEF 2017, 'DNA‐Interacting characteristics of the archaeal Rudiviral protein SIRV2_Gp1' Viruses, vol 9, no. 7, 190. DOI: 10.3390/v9070190
Morten, MJ, Gamsjaeger, R, Cubeddu, L, Kariawasam, R, Peregrina, JR, Penedo-Esteiro, JC & White, MF 2017, 'High-affinity RNA binding by a hyperthermophilic single-stranded DNA-binding protein' Extremophiles, vol 21, no. 2, pp. 369-379. DOI: 10.1007/s00792-016-0910-2
Han, W, Li, Y, Deng, L, Feng, M, Peng, W, Hallstrøm, S, Zhang, J, Peng, N, Liang, YX, White, MF & She, Q 2017, 'A type III-B CRISPR–Cas effector complex mediating massive target DNA destruction' Nucleic Acids Research, vol 45, no. 4, pp. 1983-1993. DOI: 10.1093/nar/gkw1274
White, MF 2016, 'Cpf1 shape-shifts for streamlined CRISPR cleavage' Nature Structural and Molecular Biology, vol 23, no. 5, pp. 365-6. DOI: 10.1038/nsmb.3225
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