Prof Malcolm White


BMS 307 Annexe
tel. 01334 463432
fax. 01334 462595

Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and  DNA repair mechanisms. We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics.

The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectrometry and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.



White, MF & Allers, T 2018, 'DNA repair in the Archaea – an emerging picture' FEMS Microbiology Reviews, vol Advance articles. DOI: 10.1093/femsre/fuy020
Rollie, C, Graham, S, Rouillon, C & White, MF 2018, 'Prespacer processing and specific integration in a Type I-A CRISPR system' Nucleic Acids Research, vol 46, no. 3, pp. 1007-1020. DOI: 10.1093/nar/gkx1232
Peeters, E, Boon, M, Rollie, CJC, Willaert, RG, Voet, M, White, MF, Prangishvili, D, Lavigne, R & Quax, TEF 2017, 'DNA‐Interacting characteristics of the archaeal Rudiviral protein SIRV2_Gp1' Viruses, vol 9, no. 7, 190. DOI: 10.3390/v9070190
Morten, MJ, Gamsjaeger, R, Cubeddu, L, Kariawasam, R, Peregrina, JR, Penedo-Esteiro, JC & White, MF 2017, 'High-affinity RNA binding by a hyperthermophilic single-stranded DNA-binding protein' Extremophiles, vol 21, no. 2, pp. 369-379. DOI: 10.1007/s00792-016-0910-2
Han, W, Li, Y, Deng, L, Feng, M, Peng, W, Hallstrøm, S, Zhang, J, Peng, N, Liang, YX, White, MF & She, Q 2017, 'A type III-B CRISPR–Cas effector complex mediating massive target DNA destruction' Nucleic Acids Research, vol 45, no. 4, pp. 1983-1993. DOI: 10.1093/nar/gkw1274
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