Targeting the Cytoplasmic Iron-Sulphur Cluster Assembly Machinery to Disrupt Trypanosome Genome Integrity
Maiko Tonini is a biology PhD student funded by the Science without Borders programme and is jointly supervised by Dr Terry Smith and Dr Stuart MacNeill.
Maiko has a degree in Pharmacy and Biochemistry from the University of Joinville (Brazil) and during his time as an undergraduate, was a funded student involved in projects of pre-clinical in vivo assessment of natural products with medicinal potential. In 2013 he graduated with a Master degree in Biotechnology and Bioscience from the Federal University of Santa Catarina (Brazil). As a Masters student, he developed a colorimetric microplate assay for screening of active compounds against the intracellular form of the parasite Leishmania amazonensis and also contributed for the evaluation of different classes of natural and synthetic compounds with in vitro activity against T. cruzi and Leishmania spp.
Currently, Maiko works towards the genetic validation of the cytoplasmic iron sulphur cluster assembly machinery as a novel target to disrupt the genomic stability in trypanosomes and the identification of compounds able to inhibit this pathway.