Dr Rafael Guimaraes da Silva

Research Fellow

BMS B103
tel. 01334 463496

  • Research Fellow (2015-Present) - University of St Andrews, St Andrews, UK

  • Principal Scientist (2014) - Pfizer, Groton, USA

  • Senior Scientist (2012-2013) - Pfizer, Groton, USA

  • Post-Doctoral Associate (2008-2012) - Albert Einstein College of Medicine, New York, USA

                  Adviser: Dr. Vern L. Schramm

  • D.Sc. - Biochemistry  (2008) - Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

                  Adviser: Dr. Luiz A. Basso

  • M.Sc. - Biochemistry (2005) - Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

                  Adviser: Dr. Luiz A. Basso

  • B.Sc. - Biology (2002) - Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil



McAllister, L, Butler, C, Mente, S, O'Neil, SV, Fonseca, K, Piro, J, Cianfrogna, J, Foley, T, Gilbert, A, Harris, A, Helal, CJ, Johnson, DS, Montgomery, JI, Nason, DM, Noell, S, Pandit, J, Rogers, BN, Samad, TA, Shaffer, CL, da Silva, RG, Uccello, DP, Webb, D & Brodney, MA 2018, 'Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation' Journal of Medicinal Chemistry, vol 61, no. 7, pp. 3008–3026. DOI: 10.1021/acs.jmedchem.8b00070
Stroek, R, Ge, Y, Talbot, PD, Glok, MK, Bernas, KE, Thomson, CM, Gould, ER, Alphey, MS, Liu, H, Florence, GJ, Naismith, JH & da Silva, RG 2017, 'Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase' Biochemistry, vol 56, no. 5, pp. 793-803. DOI: 10.1021/acs.biochem.6b01138
Silva, RG, Geoghegan, KF, Qiu, X & Aulabaugh, A 2014, 'A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity' Analytical Biochemistry, vol 450, no. 1, pp. 63-69. DOI: doi:10.1016/j.ab.2014.01.007
Neto, BAD, Correa, JR & Silva, RG 2013, 'Selective mitochondrial staining with small fluorescent probes: importance, design, synthesis, challenges and trends for new markers' RSC Advances, vol 3, pp. 5291-5301. DOI: DOI: 10.1039/C2RA21995F
Ramos, LM, Guido, BC, Nobrega, CC, Correa, JR, Silva, RG, de Oliveira, HCB, Gomes, AF, Gozzo, FC & Neto, BAD 2013, 'The Biginelli reaction with an imidazolium-tagged recyclable iron catalyst: kinetics, mechanism, and antitumoral activity' Chemistry - A European Journal, vol 19, pp. 4156-4168. DOI: DOI: 10.1002/chem.201204314
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Dr Rafael Guimaraes da Silva
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST

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