Prof Terry Smith

Professor

BMS B310
tel. 01334-463412
fax. 01334 462595
tks1@st-andrews.ac.uk

Professor Terry K. Smith is a reader in both the school of chemistry and the school of biology at the University of St Andrews, Scotland. His research utilizes a wide range of disciplines to genetically and chemically validate drug targets involved in lipid metabolism of protozoan parasites that cause neglected tropical diseases such as African sleeping sickness and American Trypanosomiasis.

An interview with Terry by the International Innovation magazine can be found here.

 

Publications

Aitken, L, Baillie, G, Pannifer, A, Morrison, A, Jones, PS, Smith, TK, McElroy, SP & Gunn-Moore, FJ 2017, 'In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease' SLAS Discovery, vol 22, no. 6, pp. 676-685. DOI: 10.1177/247255521769796
Mwenechanya, R, Kovářová, J, Dickens, NJ, Mudaliar, M, Herzyk, P, Vincent, IM, Weidt, SK, Burgess, KE, Burchmore, RJS, Pountain, AW, Smith, TK, Creek, DJ, Kim, D-H, Lepesheva, GI & Barrett, MP 2017, 'Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana' PLoS Neglected Tropical Diseases, vol 11, no. 6, e0005649. DOI: 10.1371/journal.pntd.0005649
Benek, O, Hroch, L, Aitken, L, Dolezal, R, Guest, P, Benkova, M, Soukup, O, Musil, K, Hughes, R, Kuca, K, Smith, TK, Gunn-Moore, F & Musilek, K 2017, '6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: design, synthesis and in vitro evaluation' Medicinal Chemistry, vol 13, no. 4, pp. 345-358. DOI: 10.2174/1573406413666170109142725
Smith, TK, Bringaud, F, Nolan, DP & Figueiredo, LM 2017, 'Metabolic reprogramming during the Trypanosoma brucei life cycle' F1000Research, vol 6, 683. DOI: 10.12688/f1000research.10342.2
Farine, L, Jelk, J, Choi, J-Y, Voelker, DR, Nunes, J, Smith, TK & Bütikofer, P 2017, 'Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in Trypanosoma brucei' Molecular Microbiology, vol 104, no. 3, pp. 412-427. DOI: 10.1111/mmi.13637
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