speaker: Dr Will Fuller
(University of Dundee )
room: Lecture Theatre
see also: additional details
host/contact: Dr Samantha Pitt
Dr Fuller will deliver a talk entitled:
"Getting to grips with a slippery modification: why we should all care about adding fats to proteins"
Abstract: Reversible post-translational modifications are the key to acutely changing cellular behaviour. While the role of protein phosphorylation in cell biology is well-established, protein S-palmitoylation (the reversible conjugation of the fatty acid palmitate to protein cysteines) has only recently emerged as a common and functionally important reversible post-translational modification in a variety of tissues. Protein S-palmitoylation is catalysed by a family of protein acyltransferases, reversed by protein thioesterases, and occurs dynamically and reversibly throughout the secretory pathway in a manner analogous to protein phosphorylation.
In cardiac muscle the generation of force is linked to tissue excitability by the movement of sodium and calcium ions across cell surface and intracellular membranes. We find every quantitatively significant route by which these ions cross membranes is palmitoylated in the heart. In this seminar I will describe the regulation of cardiac ion transporters by palmitoylation, the molecular control of protein palmitoylation in the heart, and discuss how this may be relevant in cardiac diseases.
Biography: Dr Fuller completed a BA and PhD in Pharmacology at the University of Cambridge. He then moved to King's College London where he worked on regulation of the cardiac sodium pump in the laboratory of Professor Michael Shattock. During 8 years in this lab Dr Fuller developed interests in the regulation of cardiac ion transport and post-translational modifications - working first on the sodium pump, and later on its cardiac accessory protein phospholemman.
He established his own lab in Dundee in 2006.
The overall research theme in the Fuller laboratory is the organisation and dynamic regulation of signalling complexes in cardiac muscle during health and disease, with particular reference to regulation of cardiac ion transporters. They employ a variety of subcellular fractionation, imaging, affinity purification, biochemical and cell and organ physiological techniques to investigate molecular, macromolecular, whole cell and whole organ behaviours.